2025
Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.
Blaum N, Ghelani T, Götz TWB, Chronister KS, Bengochea M, Ceresnova L, Christensen CF, Moulin TC, Kern H, Thomas U, Heine M, Sigrist SJ, Walter AM.
Proc Natl Acad Sci USA. 2025 Aug 26;122(34): doi: 10.1073/pnas.2514151122, Epub 2025 Aug 20.PMID: 40833403,
Unreliable homeostatic action potential broadening in cultured dissociated neurons.
Ritzau-Jost A, Rajayer S, Nerlich J, Maciag F, John A, Russier M, Sabater VG, Steiger LJ, Coq JO, Eilers J, Engelhardt M, Burrone J, Debanne D, Heine M, Smith SM, Hallermann S.
bioRxiv [Preprint]. 2025 May 15, doi: 10.7554/eLife.106995.1.sa3. PMID: 40463064
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms.
Bell C, Kilo L, Gottschalk D, Arian J, Deneke L, Kern H, Rickert C, Kobler O, Strauß J, Heine M, Duch C, Ryglewski S.
eLife. 2025 Feb 14;13:RP100394. doi: 10.7554/eLife.100394. PMID: 39951027
Blobby is a synaptic active zone assembly protein required for memory in Drosophila.
Lützkendorf J, Matkovic-Rachid T, Liu S, Götz T, Gao L, Turrel O, Maglione M, Grieger M, Putignano S, Ramesh N, Ghelani T, Neumann A, Gimber N, Schmoranzer J, Stawrakakis A, Brence B, Baum D, Ludwig K, Heine M, Mielke T, Liu F, Walter AM, Wahl MC, Sigrist SJ.
Nat Commun. 2025 Jan 2;16(1):271. doi: 10.1038/s41467-024-55382-9. PMID: 39747038
2024
Cortexa: a comprehensive resource for studying gene expression and alternative splicing in the murine brain.
Weißbach S, Milkovits J, Pastore S, Heine M, Gerber S, Todorov H. BMC Bioinformatics. 2024 Sep 5;25(1):293. doi: 10.1186/s12859-024-05919-y. PMID: 39237879
Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions.
Maciąg F, Chhikara A, Heine M.
Biochem Soc Trans. 2024 Aug 28;52(4):1617-1629. doi: 10.1042/BST20230819.PMID: 38934485
Inhibiting presynaptic calcium channel motility in the auditory cortex suppresses synchronized input processing.
Deane KE, Klymentiev R, Heck J, Mark MD, Ohl FW, Heine M, Happel MFK.
Front Cell Neurosci. 2024 Apr 10;18:1369047. doi: 10.3389/fncel.2024.1369047. eCollection 2024.PMID: 38660672
2023
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation.
Ghelani T, Escher M, Thomas U, Esch K, Lützkendorf J, Depner H, Maglione M, Parutto P, Gratz S, Matkovic-Rachid T, Ryglewski S, Walter AM, Holcman D, O'Connor Giles K, Heine M*, Sigrist SJ*.
Sci Adv. 2023 Feb 17;9(7):eade7804. doi: 10.1126/sciadv.ade7804. Epub 2023 Feb 17. PMID: 36800417
2022
High-throughput super-resolution single-particle trajectory analysis reconstructs organelle dynamics and membrane reorganization.
Parutto P, Heck J, Lu M, Kaminski C, Avezov E, Heine M, Holcman D. (2022)
Cell Rep Methods 2: 100277. DOI: 10.1016/j.crmeth.2022.100277, PMID: 36046627
The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membranes.
Krzysko J, Maciag F, Mertens A, Güler BE, Linnert J, Boldt K, Ueffing M, Nagel-Wolfrum K, Heine M, Wolfrum U. (2022)
Cells 11: 2790.
2021
Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca2+ pump PMCA.
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2106621118. doi: 10.1073/pnas.2106621118.
Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.
Cell Rep. 2021 Jun 15;35(11):109266. doi: 10.1016/j.celrep.2021.109266.
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
Channels (Austin). 2021 Dec;15(1):322-338. doi: 10.1080/19336950.2021.1900024.
2020
Asymmetry between pre- and postsynaptic transient nanodomains shapes neuronal communication.
Heine M, Holcman D (2020)
Trends Neurosci 43:182-196 doi: 10.1016/j.tins.2020.01.005.
Auxiliary α2δ1 and α2δ3 subunits of calcium channels drive excitatory and inhibitory neuronal network development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M (2020)
J Neurosci 40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020.
2019
Biophysics of high density nanometer regions extracted from super-resolution single particle trajectories: application to voltage-gated calcium channels and phospholipids.
Parutto P, Heck J, Heine M, Holcman D (2019)
Sci Rep 9:18818. doi: 10.1038/s41598-019-55124-8.
Fast regulation of GABAAR diffusion dynamics by Nogo-A signaling.
Fricke S, Metzdorf K, Ohm M, Haak S, Heine M, Korte M, Zagrebelsky M (2019)
Cell Rep 29:671-684.e6. doi: 10.1016/j.celrep.2019.09.015.
Transient confinement of CaV2.1 Ca2+-channel splice variants shapes synaptic short-term plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M (2019)
Neuron 103(1):66-79.e12. doi: 10.1016/j.neuron.2019.04.030.
Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis.
van Loo K, Rummel C, Pitsch J, Müller JA, Bikbaev A, Chavez EM, Blaess S, Dietrich D, Heine M, Becker A, and Schoch S (2019)
J Neurosci
2018
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane.
Taylor RD, Heine M, Emptage NJ, Andreae LC (2018)
iScience 10:234-244. doi: 10.1016/j.isci.2018.12.001.
α-Neurexins together with α2δ-1 auxiliary subunits regulate Ca2+ influx through Cav2.1 channels.
Brockhaus J, Schreitmüller M, Repetto D, Klatt O, Reissner C, Elmslie K, Heine M, Missler M (2018)
J Neurosci 38(38):8277-8294. doi: 10.1523/JNEUROSCI.0511-18.2018.
Noelin1 affects lateral mobility of synaptic AMPA receptors.
Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson UH, Li KW, Heine M, Spijker S, Frischknecht R, Smit AB (2018)
Cell Rep 24:1218-1230. doi: 10.1016/j.celrep.2018.06.102.
The low-threshold calcium channel Cav3.2 mediates burst firing of mature dentate granule cells.
Dumenieu M, Senkov O, Mironov A, Bourinet E, Kreutz MR, Dityatev A, Heine M, Bikbaev A*, Lopez-Rojas J* (2018)
Cereb Cortex 28(7):2594-2609. (*equal corresponding) doi: 10.1093/cercor/bhy084.
Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons.
Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V (2018)
J Biol Chem. 293(3):1040-1053. doi: 10.1074/jbc.M117.799585.
2017
Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors.
Schweitzer B, Singh J, Fejtova A, Groc L, Heine M, Frischknecht R (2017)
Sci Rep 7:10991. doi: 10.1038/s41598-017-07003-3.
2016
Dynamic association of calcium channel subunits at the cellular membrane.
Voigt A, Freund R, Heck J, Missler M, Obermair GJ, Thomas U, Heine M (2016)
Neurophotonics 3:041809. doi: 10.1117/1.nph.3.4.041809.
Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus.
Lopez-Rojas J, Heine M, Kreutz MR (2016)
Sci Rep 6:21615. doi: 10.1038/srep21615.
2015
Fast three-dimensional single-particle tracking in natural brain tissue.
Sokoll S, Prokazov Y, Hanses M, Biermann B, Tönnies K, Heine M (2015)
Biophys J 109(7):1463-71. doi: 10.1016/j.bpj.2015.07.047.
Regulated dynamic trafficking of neurexins inside and outside of synaptic terminals.
Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, Niesmann K, Missler M, Heine M (2015)
J Neurosci 35(40):13629-13647. doi: 10.1523/jneurosci.4041-14.2015.
Brain extracellular matrix retains connectivity in neuronal networks.
Bikbaev A*, Frischknecht R, Heine M* (2015)
Sci Rep 5:14527. (*equal corresponding) doi: 10.1038/srep14527.
Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca channels.
Garau G, Magotti P, Heine M, Korotchenko S, Lievens PM, Berezin V, Dityatev A (2015)
Exp Neurol 274(Pt B):156-65. doi: 10.1016/j.expneurol.2015.08.006.
Mobility of calcium channels in the presynaptic membrane.
Schneider R, Hosy E, Kohl J, Klyueva Y, Choquet D, Thomas U, Voigt A, Heine M (2015)
Neuron 86(3):672-9. doi: 10.1016/j.neuron.2015.03.050.
2014
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U (2014)
Cell Commun Signal 12(1):75. doi: 10.1186/s12964-014-0075-5.
Intracellular Ca2+ and not the extracellular matrix determine surface dynamics of AMPA-type glutamate receptors on aspiny neurons.
Klueva J, Gundelfinger ED, Frischknecht R, Heine M (2014)
Philos Trans R Soc Lond B Biol Sci 369(1654). doi: 10.1098/rstb.2013.0605.
Modulation of synaptic function through the α-Neurexin-specific ligand Neurexophilin-1.
Born G, Breuer D, Wang S, Rohlmann A, Coulon P, Vakili P, Reissner C, Kiefer F, Heine M, Pape H-C, Missler M (2014)
Proc Natl Acad Sci U S A. 111(13): E1274-1283. doi: 10.1073/pnas.1312112111.
Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein.
Davydova D, Marini C, King C, Klueva J, Bischof F, Romorini S, Montenegro-Venegas C, Heine M, Schneider R, Schröder MS, Altrock WD, Henneberger C, Rusakov DA, Gundelfinger ED, Fejtova A (2014)
Neuron 82(1):181-194. doi: 10.1016/j.neuron.2014.02.012.
Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
Szepesi Z, Hosy E, Ruszczycki B, Bijata M, Pyskaty M, Bikbaev A, Heine M, Choquet D, Kaczmarek L, Wlodarczyk J (2014)
PLoS One 9(5): e98274. doi: 10.1371/journal.pone.0098274.
Imaging of molecular surface dynamics in brain slices using single-particle tracking.
Biermann B, Sokoll S, Klueva J, Missler M, Wiegert JS, Sibarita JB, Heine M (2014)
Nat Commun 5:3024. doi: 10.1038/ncomms4024.
Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.
Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D (2014)
J Biol Chem. 289(13): 8973-8988. doi: 10.1074/jbc.m113.514992.
Immunosuppression by NMDA-receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M*, Bommhardt U* (2014)
Mol Cell Biol 34(5):820-31. (*equal corresponding) doi: 10.1128/mcb.01273-13.
2013
An online calibration method for astigmatism-based 3D particle tracking in complex living tissue.
Sokoll S, Tonnies K, Heine M (2013)
Proceedings - International Symposium on Biomedical Imaging 6556442:181-184. doi: 10.1109/ISBI.2013.6556442.
2012
Detection of spontaneous vesicle release at individual synapses using multiple wavelets in a CWT-based algorithm.
Sokoll S, Tönnies K, Heine M (2012)
Med Image Comput Comput Assist Interv. 15:165-72. doi: 10.1007/978-3-642-33415-3_21.
Unified quantitative model of AMPA receptor trafficking at synapses.
Czöndör K, Mondin M, Garcia M, Heine M, Frischknecht R, Choquet D, Sibarita JB, Thoumine OR (2012)
Proc Natl Acad Sci U S A. 109(9):3522-7. doi: 10.1073/pnas.1109818109.
2011
Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons.
Di Biase V, Tuluc P, Campiglio M, Obermair GJ, Heine M*, Flucher BE* (2011)
J Neurosci 31(38):13682-13694. (*equal corresponding) doi: 10.1523/jneurosci.2300-11.2011.
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A (2011)
J Neurosci 31(28):10189-10200. doi: 10.1523/JNEUROSCI.2088-11.2011.
2010
Tracking of fast moving neuronal vesicles with ageladine A.
Bickmeyer U, Heine M, Podbielski I, Münd D, Köck M, Karuso P. (2010)
Biochem Biophys Res Commun. 402:489-94
2009
The brain extracellular matrix limits lateral diffusion of AMPA receptors and modulates short-term synaptic plasticity.
Frischknecht R, Heine M*, Seidenbecher C, Choquet D, Gundelfinger E D. (2009)
Nat Neurosci 12: 897-904. (*equeal contribution)
2008
Surface mobility of postsynaptic AMPARs tunes synaptic transmission.
Heine M, Groc L, Frischknecht R, Béïque JC, Lounis B, Rumbaugh G, Huganir RL, Cognet L, Choquet D. (2008)
Science. 320: 201-5.
Neurexin-neurologin contacts rapidly recruit functional NMDA and AMPA receptors.
Heine M, Thoumine O, Giannone G, Tessier B, Choquet D. (2008)
Proc Natl Acad Sci U S A 105: 20947-52.
2007
Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity.
Ehlers MD, Heine M, Groc L, Lee MC, and Choquet D. (2007).
Neuron. 54:447-460. (Faculty of 1000)
Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategies.
Groc L, Lafourcade M, Heine M, Renner M, Racine V, Sibarita JB, Lounis B, Choquet D, and Cognet L. (2007).
J Neurosci. 27:12433-12437.
2006
Single nanoparticle photothermal tracking (SNaPT) of 5-nm gold beads in live cells.
Lasne D, Blab GA, Berciaud S, Heine M, Groc L, Choquet D, Cognet L, and Lounis B. (2006).
Biophys J. 91: 4598-4604.
Single molecule, CdSe/ZnS quantum dot and gold nanoparticle detection in live neurons.
Lasne, D., L. Cognet, S. Berciaud, G.A. Blab G, L. Groc, M. Heine, D. Choquet and B. Lounis. (2006).
Proc. SPIE 6096: 9616-9616; Editors : M. Osinski, K. Yamamoto, T.M. Jovin
NMDA receptor surface mobility depends on NR2A-2B subunits.
Groc L, Heine M, Cousins SL, Stephenson FA, Lounis B, Cognet L and Choquet D. (2006).
Proc Natl Acad Sci U S A 103:18769-18774.
2005
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.
Ponimaskin, E., A. Dumuis, F. Gaven, G. Barthet, M. Heine, K. Glebov, D.W. Richter, and M. Oppermann. (2005).
Mol Pharmacol. 67:1434-1443.
2004
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.
Groc L, Heine M, Cognet L, Brickley K, Stephenson FA, Lounis B, and Choquet D. (2004).
Nat Neurosci. 7:695-696.
2002
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.
Ponimaskin EG, Heine M, Joubert L, Sebben M, Bickmeyer U, Richter DW, Dumuis A. (2002).
J Biol Chem. 277: 2534-46.
5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel.
Heine M, Ponimaskin E, Bickmeyer U, Richter DW. (2002).
Pflügers Arch. 443: 418-26.
Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons.
Bickmeyer U, Heine M*, Manzke T, Richter DW. (2002).
Eur J Neurosci. 16: 209 -18. (*equal contribution)
2001
5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner.
Ponimaskin EG, Schmidt MF, Heine M, Bickmeyer U, Richter DW. (2001).
Biochem J. 353: 627-34.
Calcium-induced calcium release in neurosecretory insect neurons: fast and slow responses.
Messutat S, Heine M, Wicher D. (2001).
Cell Calcium. 30: 199-211.
1998
1998 Ca2+ resting current and Ca2+-induced Ca2+ release in insect neurosecretory neurons.
Heine M, Wicher D.
Neuroreport. 9: 3309-14.