Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation
doi: 10.1126/sciadv.ade7804. Epub 2023 Feb 17.
Parutto P, Heck J, Lu M, Kaminski C, Avezov E, Heine M, Holcman D. (2022) High-throughput super-resolution single-particle trajectory analysis reconstructs organelle dynamics and membrane reorganization. Cell Rep Methods 2: 100277.
Krzysko J, Maciag F, Mertens A, Güler BE, Linnert J, Boldt K, Ueffing M, Nagel-Wolfrum K, Heine M, Wolfrum U. (2022) The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membranes. Cells 11: 2790.
Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca2+ pump PMCA. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2106621118. doi: 10.1073/pnas.2106621118.
Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior. Cell Rep. 2021 Jun 15;35(11):109266. doi: 10.1016/j.celrep.2021.109266.
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation. Channels (Austin). 2021 Dec;15(1):322-338. doi: 10.1080/19336950.2021.1900024.
Heine M, Holcman D (2020)
Asymmetry between pre- and postsynaptic transient nanodomains shapes neuronal communication. Trends Neurosci 43:182-196 doi: 10.1016/j.tins.2020.01.005.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M (2020)
Auxiliary α2δ1 and α2δ3 subunits of calcium channels drive excitatory and inhibitory neuronal network development. J Neurosci 40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020.
Parutto P, Heck J, Heine M, Holcman D (2019)
Biophysics of high density nanometer regions extracted from super-resolution single particle trajectories: application to voltage-gated calcium channels and phospholipids. Sci Rep 9:18818. doi: 10.1038/s41598-019-55124-8.
Fricke S, Metzdorf K, Ohm M, Haak S, Heine M, Korte M, Zagrebelsky M (2019)
Fast regulation of GABAAR diffusion dynamics by Nogo-A signaling. Cell Rep 29:671-684.e6. doi: 10.1016/j.celrep.2019.09.015.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M (2019)
Transient confinement of CaV2.1 Ca2+-channel splice variants shapes synaptic short-term plasticity.
Neuron 103(1):66-79.e12. doi: 10.1016/j.neuron.2019.04.030.
van Loo K, Rummel C, Pitsch J, Müller JA, Bikbaev A, Chavez EM, Blaess S, Dietrich D, Heine M, Becker A, and Schoch S (2019)
Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis. J Neurosci
Taylor RD, Heine M, Emptage NJ, Andreae LC (2018)
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane.
iScience 10:234-244. doi: 10.1016/j.isci.2018.12.001.
Brockhaus J, Schreitmüller M, Repetto D, Klatt O, Reissner C, Elmslie K, Heine M, Missler M (2018)
α-Neurexins together with α2δ-1 auxiliary subunits regulate Ca2+ influx through Cav2.1 channels. J Neurosci 38(38):8277-8294. doi: 10.1523/JNEUROSCI.0511-18.2018.
Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson UH, Li KW, Heine M, Spijker S, Frischknecht R, Smit AB (2018)
Noelin1 affects lateral mobility of synaptic AMPA receptors. Cell Rep 24:1218-1230. doi: 10.1016/j.celrep.2018.06.102.
Dumenieu M, Senkov O, Mironov A, Bourinet E, Kreutz MR, Dityatev A, Heine M, Bikbaev A*, Lopez-Rojas J* (2018)
The low-threshold calcium channel Cav3.2 mediates burst firing of mature dentate granule cells. Cereb Cortex 28(7):2594-2609. (*equal corresponding) doi: 10.1093/cercor/bhy084.
Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V (2018)
Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons. J Biol Chem. 293(3):1040-1053. doi: 10.1074/jbc.M117.799585.
Schweitzer B, Singh J, Fejtova A, Groc L, Heine M, Frischknecht R (2017)
Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors. Sci Rep 7:10991. doi: 10.1038/s41598-017-07003-3.
Voigt A, Freund R, Heck J, Missler M, Obermair GJ, Thomas U, Heine M (2016)
Dynamic association of calcium channel subunits at the cellular membrane. Neurophotonics 3:041809. doi: 10.1117/1.nph.3.4.041809.
Lopez-Rojas J, Heine M, Kreutz MR (2016)
Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus. Sci Rep 6:21615. doi: 10.1038/srep21615.
Sokoll S, Prokazov Y, Hanses M, Biermann B, Tönnies K, Heine M (2015)
Fast three-dimensional single-particle tracking in natural brain tissue. Biophys J 109(7):1463-71. doi: 10.1016/j.bpj.2015.07.047.
Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, Niesmann K, Missler M, Heine M (2015)
Regulated dynamic trafficking of neurexins inside and outside of synaptic terminals. J Neurosci 35(40):13629-13647. doi: 10.1523/jneurosci.4041-14.2015.
Bikbaev A*, Frischknecht R, Heine M* (2015)
Brain extracellular matrix retains connectivity in neuronal networks. Sci Rep 5:14527. (*equal corresponding) doi: 10.1038/srep14527.
Garau G, Magotti P, Heine M, Korotchenko S, Lievens PM, Berezin V, Dityatev A (2015)
Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca channels. Exp Neurol 274(Pt B):156-65. doi: 10.1016/j.expneurol.2015.08.006.
Schneider R, Hosy E, Kohl J, Klyueva Y, Choquet D, Thomas U, Voigt A, Heine M (2015)
Mobility of calcium channels in the presynaptic membrane. Neuron 86(3):672-9. doi: 10.1016/j.neuron.2015.03.050.
Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U (2014)
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Cell Commun Signal 12(1):75. doi: 10.1186/s12964-014-0075-5.
Klueva J, Gundelfinger ED, Frischknecht R, Heine M (2014)
Intracellular Ca2+ and not the extracellular matrix determine surface dynamics of AMPA-type glutamate receptors on aspiny neurons. Philos Trans R Soc Lond B Biol Sci 369(1654). doi: 10.1098/rstb.2013.0605.
Born G, Breuer D, Wang S, Rohlmann A, Coulon P, Vakili P, Reissner C, Kiefer F, Heine M, Pape H-C, Missler M (2014)
Modulation of synaptic function through the α-Neurexin-specific ligand Neurexophilin-1. Proc Natl Acad Sci U S A. 111(13): E1274-1283. doi: 10.1073/pnas.1312112111.
Davydova D, Marini C, King C, Klueva J, Bischof F, Romorini S, Montenegro-Venegas C, Heine M, Schneider R, Schröder MS, Altrock WD, Henneberger C, Rusakov DA, Gundelfinger ED, Fejtova A (2014)
Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein. Neuron 82(1):181-194. doi: 10.1016/j.neuron.2014.02.012.
Szepesi Z, Hosy E, Ruszczycki B, Bijata M, Pyskaty M, Bikbaev A, Heine M, Choquet D, Kaczmarek L, Wlodarczyk J (2014)
Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors. PLoS One 9(5): e98274. doi: 10.1371/journal.pone.0098274.
Biermann B, Sokoll S, Klueva J, Missler M, Wiegert JS, Sibarita JB, Heine M (2014)
Imaging of molecular surface dynamics in brain slices using single-particle tracking. Nat Commun 5:3024. doi: 10.1038/ncomms4024.
Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D (2014)
Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. J Biol Chem. 289(13): 8973-8988. doi: 10.1074/jbc.m113.514992.
Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M*, Bommhardt U* (2014)
Immunosuppression by NMDA-receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells. Mol Cell Biol 34(5):820-31. (*equal corresponding) doi: 10.1128/mcb.01273-13.
Sokoll S, Tonnies K, Heine M (2013)
An online calibration method for astigmatism-based 3D particle tracking in complex living tissue. Proceedings - International Symposium on Biomedical Imaging 6556442:181-184. doi: 10.1109/ISBI.2013.6556442.
Sokoll S, Tönnies K, Heine M (2012)
Detection of spontaneous vesicle release at individual synapses using multiple wavelets in a CWT-based algorithm. Med Image Comput Comput Assist Interv. 15:165-72. doi: 10.1007/978-3-642-33415-3_21.
Czöndör K, Mondin M, Garcia M, Heine M, Frischknecht R, Choquet D, Sibarita JB, Thoumine OR (2012) Unified quantitative model of AMPA receptor trafficking at synapses. Proc Natl Acad Sci U S A. 109(9):3522-7. doi: 10.1073/pnas.1109818109.
Di Biase V, Tuluc P, Campiglio M, Obermair GJ, Heine M*, Flucher BE* (2011)
Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons. J Neurosci 31(38):13682-13694. (*equal corresponding) doi: 10.1523/jneurosci.2300-11.2011.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A (2011)
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci 31(28):10189-10200. doi: 10.1523/JNEUROSCI.2088-11.2011.
Bickmeyer U, Heine M, Podbielski I, Münd D, Köck M, Karuso P. (2010) Tracking of fast moving neuronal vesicles with ageladine A, Biochem Biophys Res Commun. 402:489-94
FrischknechtR, Heine M*, Seidenbecher C, Choquet D, Gundelfinger E D. (2009) The brain extracellular matrix limits lateral diffusion of AMPA receptors and modulates short-term synaptic plasticity, Nat Neurosci 12: 897-904. (*equeal contribution)
Heine M, Groc L, Frischknecht R, Béïque JC, Lounis B, Rumbaugh G, Huganir RL, Cognet L, Choquet D. (2008) Surface mobility of postsynaptic AMPARs tunes synaptic transmission. Science. 320: 201-5.
Heine M, Thoumine O, Giannone G, Tessier B, Choquet D. (2008) Neurexin-neurologin contacts rapidly recruit functional NMDA and AMPA receptors, Proc Natl Acad Sci U S A 105: 20947-52.
Ehlers MD, Heine M, Groc L, Lee MC, and Choquet D. (2007). Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity. Neuron. 54:447-460. (Faculty of 1000)
Groc L, Lafourcade M, Heine M, Renner M, Racine V, Sibarita JB, Lounis B, Choquet D, and Cognet L. (2007). Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategies. J Neurosci. 27:12433-12437.
Lasne D, Blab GA, Berciaud S, Heine M, Groc L, Choquet D, Cognet L, and Lounis B. (2006). Single nanoparticle photothermal tracking (SNaPT) of 5-nm gold beads in live cells. Biophys J. 91: 4598-4604.
Lasne, D., L. Cognet, S. Berciaud, G.A. Blab G, L. Groc, M. Heine, D. Choquet and B. Lounis. (2006). Single molecule, CdSe/ZnS quantum dot and gold nanoparticle detection in live neurons. Proc. SPIE 6096: 9616-9616; Editors : M. Osinski, K. Yamamoto, T.M. Jovin
Groc L, Heine M, Cousins SL, Stephenson FA, Lounis B, Cognet L and Choquet D. (2006). NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci U S A 103:18769-18774.
Ponimaskin, E., A. Dumuis, F. Gaven, G. Barthet, M. Heine, K. Glebov, D.W. Richter, and M. Oppermann. (2005). Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis. Mol Pharmacol. 67:1434-1443.
Groc L, Heine M, Cognet L, Brickley K, Stephenson FA, Lounis B, and Choquet D. (2004). Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nat Neurosci. 7:695-696.
Ponimaskin EG, Heine M, Joubert L, Sebben M, Bickmeyer U, Richter DW, Dumuis A. 2002 The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity. J Biol Chem. 277: 2534-46.
Heine M, Ponimaskin E, Bickmeyer U, Richter DW. (2002). 5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel. Pflügers Arch. 443: 418-26.
Bickmeyer U, Heine M*, Manzke T, Richter DW. (2002). Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons. Eur J Neurosci. 16: 209 -18. (*equeal contribution)
Ponimaskin EG, Schmidt MF, Heine M, Bickmeyer U, Richter DW. (2001).5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner. Biochem J. 353: 627-34.
Messutat S, Heine M, Wicher D. (2001). Calcium-induced calcium release in neurosecretory insect neurons: fast and slow responses. Cell Calcium. 30: 199-211.
Heine M, Wicher D. 1998 Ca2+ resting current and Ca2+-induced Ca2+ release in insect neurosecretory neurons. Neuroreport. 9: 3309-14.